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Cooking up a custom envelope

Custom envelopes are a popular choice for various direct marketing campaigns and formal business communications.chocolate ugg boots They provide a good cover type presentation for letters and other marketing materials so that readers can be attracted to read them. That is why a lot of effort and imagination are invested in envelope printing designs so that they can capture the attention of these potential readers before they decide to throw the mail as junk. For people just starting out in making custom envelopes, below are the 7 steps on how to cook up your own envelopers. Before that though, you need to know the ingredients.ugg boots for cheaper Custom envelope ingredients: White Envelopes (printer compliant) or full color envelopes (if you want), a Computer, Printer, Imaging Software (i.e. Photoshop), Publishing Software (Microsoft Publisher/Word), Envelope Template (optional), Company or Project image, Supplemental images. 1. Write down or type up the envelope content Before doing anything,cheap uggs outlet store you need to first decide on what you actually want to put into your custom envelope. Do you want to print the company's name and address? Do you want to add the company's slogan? Are there any other details that need to be written down? Just write them up on a piece of paper for reference. Better yet, you may want to type them in the Windows Notepad application so that you can copy and paste it later. 2. Look for your images Next, collect the images that you want to use for the envelope. Typically you may want to obtain a digital file of your company's logo to act as an identifying mark one custom envelope. Besides that, if you are going to use an advertising image on the envelope, try to have that image ready for insertion later on. Make sure that your images are in a high resolution format so that you can prevent some pixilation to occur.uggs clearance sale 3. Download templates (optional) - If you want an even easier time in envelope printing, then you can look for an online envelope printing service over the Internet and see if they have any templates for envelopes. Most printing companies should have a few ready for display. Some might even offer the templates free for download. Just try and look for the best envelope template that you can which matches your concept for your custom envelope. Gather what you can and then fire up your image editing and publishing software. 4. Start up the Wizard (optional) If your software has a setup wizard, then you should have no trouble in making a custom envelope. Start your wizard and then enter the details of the software as each question is displayed, including the images. ugg boots sale clearance Once you are done, you actually will have a custom envelope already for printing. 5. Enter details into your software Of course for those who don't have a wizard in their publishing software, you will need to do this by hand. For starters just type in the pertinent details for your custom envelope designs in your document. Don't go for full formatting yet at this state since you may get lost easily in the process. Just type in or insert all the text and image details that you want included for now. 6. Formatting your Layout Once you have the raw data in your custom envelope document, start formatting the elements that we inserted. Try to block the sender's address and receiver's address on appropriate but unique places.ugg boots sale stores Experiment with your fonts and images so that they compliment the overall look of the page. Determine the right text color your envelope covers and messages. Basically make sure that everything is pleasing to die and has a professional stuff. 7. Print Once your envelope design is done, all you have to do is to print them up. Most of the printers today have special slots and settings that you may need as you print your custom envelopes. If the printer feature matches, then you should already have no trouble in printing them. Make sure that you are envelopes are printed in the best envelope paper available as well to maintain print quality.ugg boots sale online 8. Paste (optional) Lastly, depending on the envelope that you created, you may need to paste the various corners of your actual envelopes so that they look like a normal envelope. Place the past and fold the corners of the envelopers to make it ready for delivery. Otherwise, if your printer is high-tech, then it can print your custom envelopes even though they are folded. Great! Follow these steps and you should have a nice custom envelope that you can create in your home or office.ugg boots sale

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Gender Selection Methods An Overview

In ancient Greece, men used to have sex lying on their right side in hopes of conceiving a son.ugg boots for cheap In medieval France, men would tie off their left testicle in order to produce a baby boy only. Sounds strange and unusual? Maybe, but the desire to choose gender of their baby is still strong among today's parents-to-be. They just don't want to rely on the same primitive (an ineffective) methods.uk uggs Today, there are cutting edge technologies available which can literally allow parents to choose the gender of their baby. Sadly, one of those methods is - selective abortion. Mother can find out the gender of her baby using amniocentesis, and then decide to have an abortion if the sex of the baby turns out not to be what she have hoped to be.cheap uggs outlet stores This gender selection method is most prevalent in those countries where, historically and culturally, boys were preferred. Fortunately, there are other options for parents eager to choose gender of their baby. None of them free of ethical considerations, though! In mid 1970's, geneticist Ronald Ericsson, PhD, developed the gender selection method that remains known as Ericsson method.uggs clearance This method sorts between male and female producing sperm and involves artificial insemination. Comparing to other gender selection methods, Ericsson method is not very expensive and invasive - however it possesses lower success rates. The cost is about 2 000 USD per circle. About three times out of ten, this gender selection method fails.buy uggs Used since 1989, preimplantation genetic diagnosis (PGD) method of gender selection involves in vitro fertilization (IVF). Doctors analyze the cells from embryos to determine its sex and consequently, only the embryo of desired gender is returned to woman's uterus. The cost is nearly 20 000 USD, but it is 100 % accurate.uggs boots sale clearance PGD carries high chances of multiples. The newest and most talked about gender selection method is a variation on Ericsson's method and is best known as Microsort. The statistics show that 86 % of parents who used this methods to conceive, did so for sex selection.ugg outlet online The cost is about 15 000 USD, and success rate is about 90 % for conceiving girls, but only 74 % for conceiving boys. Microsort method is not yet approved by the Food and Drug Administration. Let just add that, while in United States gender selection is currently allowed for both genetic and preferential reasons,usa uggs many other countries opted to regulate the whole matter much more restrictively.

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Buy Discounted Perfumes on Christmas Day

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Iran May Have Missiles from North Korea, Cables Posted by WikiLeaks Show

Iran obtained 19 advanced missiles from North Korea, potentially giving the Islamic nation the capability of attacking Moscow and cities in Western Europe, according to embassy cables posted by WikiLeaks.org and provided to the New York Times. U.S. officials denounced the release, coming on the eve of Secretary of State Hillary Clinton’s departure for a security conference in the Persian Gulf, as jeopardizing U.S. ties with foreign governments and endangering individuals. WikiLeaks began posting the cables yesterday. The 19 North Korean BM-25 missiles, based on a Russian design known as the R-27, might give Iran the “building blocks” for producing long-range missiles, according to a Feb. 24 cable posted on WikiLeaks. The cable didn’t provide specific evidence, according to the Times, which agreed not to publish the document at the Obama administration’s request. “North Korea and Iran have had a decades-long missile relationship and also most likely a nuclear relationship,” said Bruce Klingner, an analyst at the Heritage Foundation in Washington and former chief of the Central Intelligence Agency’s Korea branch. “The leaking of the classified documents provides a greater sense of confidence” for analysis conducted previously by outside experts and most recently illustrated in photos from a North Korean parade, he said. Pressured the U.S. Diplomatic cables posted by the Guardian, which also received advance copies from WikiLeaks, indicate as far back as early 2008 Saudi Arabia and other Arab governments pressed the U.S. for attacks on Iran to stop it getting a nuclear bomb, even as some expressed concern that a military strike might destabilize the region. The Obama administration has won stiffer United Nations Security Council sanctions against Iran and sealed arms agreements such as a $60 billion deal with Saudi Arabia over the next 10 years. The State Department declined to confirm information in what WikiLeaks says is more than 250,000 documents, covering a period from December 1966 through February 2010. “I can’t provide veracity of anything WikiLeaks has released to the media,” Nicole Thompson, a State Department spokeswoman, said in an interview, adding the agency’s policy is to refrain from commenting on specific leaked materials. About 9,000 documents were listed as containing information too sensitive to be shared with a foreign government, the New York Times said. None was listed as “top-secret,” according to the Times. Similar Tone Along with the Guardian of the U.K., France’s Le Monde, Spain’s El Pais and Der Spiegel of Germany obtained the WikiLeaks documents. On the threat from Iran, a cable posted by the Guardian quoted Adel al-Jubeir, the Saudi ambassador to the U.S., as citing Saudi King Abdullah’s “frequent exhortations to attack Iran and put an end” to the Iranian nuclear weapons program. The exchange took place in an April 20, 2008 meeting between al- Jubeir, then-U.S. Iraq Ambassador Ryan Crocker and U.S. Central Command commander General David Petraeus, the Guardian said. A similar tone was struck by King Hamad of Bahrain in a Nov. 4, 2009 conversation with Petraeus. King Hamad “pointed to Iran as the source of much trouble” in the region and “he argued forcefully to take action to terminate their nuclear program by whatever means necessary,” according to a classified cable. Hamad said “the danger of letting it go on is greater than the danger of stopping it,” according to the cable cited by the Guardian.

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Ex Girlfriend Guru Review - Get Your Ex Back Again by Erich Hines

Hopefully by the end of this Ex Girlfriend Guru Review you will be able to make an informed decision on whether or not this system for getting your ex girlfriend back is for you. As you may have guessed by both the name of this item and the name of this review, this item is only suitable in the event you are a male and looking to obtain your girlfriend back. To start with I would like to say that this really is a great item. I have reviewed a lot of various relationship related goods and In terms of both value for cash and effectiveness this was 1 with the greatest. Not only was the E-book and notes extremely well created and easy to understand but the Mp3s are just priceless. There are even other goods out there which charge an additional charge to obtain the notes in audio format. I cherished having all the information on audio as I myself am not a great deal of a reader. Having them on audio meant I could just lie back in bed and listen towards the full factor effortlessly. Another factor which is important when trying to get your ex girlfriend back is that the time you have to actually achieve that is a small amount of time (normally). in the event you had to read via all the information in this pack it could take a lot of time and you could be wasting time that you have to obtain your ex back. Instead the audio notes allow you to obtain all the information as fast as feasible so you can start utilizing it correct away. Around the note of time the cheat sheet you get also gives you much more or less everything you need so in the event you really are short of time you can just dive straight in utilizing this. I don't want to talk too a great deal about the sex tips because that's fro after you have acquired your ex back, but some of the stuff which is talked about is really prime notch. A couple of of it I've never heard of in my life. Just to end this ex girlfriend guru review off I would say that more than all this really is 1 with the easiest methods to use because it involves you performing extremely little as its all Psychological. This means that its not you performing the chasing for a change Its all about you performing certain issues which trigger reactions from your ex girlfriend. Some of these issues you may even have heard of but just didn't know how to use them nevertheless there was also a ton of stuff there that I just would never have dreamed of utilizing but somehow it actually works. So to round up this ex girlfriend guru review it gets my award of greatest manual for guys. You can get a detailed review on the Ex Squared System by the Ex Girlfriend Guru as well as a free day-by-day emergency plan to get your ex back before it's too late; without wasting more time,If You Really Want Your Ex Girlfriend Back You Need To Act Fast!

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Rivalry Tests Tea-Party Clout

WASHINGTON—House Republicans are embroiled in a leadership struggle just days after their sweeping electoral victory, testing how much influence tea-party passions will have on how lawmakers run the chamber.

Rep. Jeb Hensarling of Texas, who raised money for many House candidates and was deeply involved in the Republicans' campaign efforts, is running for chairman of the House Republican Conference, the No. 4 position in the House GOP, with the backing of party leaders.

His opponent is Minnesota Rep. Michele Bachmann, a favorite of tea-party activists who is known for her colorful statements. Some GOP leaders believe she would be less effective, but many tea-party activists see this as a test of whether Republicans are listening to them.

"Michele Bachmann—everybody knows she's been talking about tea-party values from the beginning of the movement," said Mark Meckler, national coordinator of the Tea Party Patriots. "What we'd like to see is the House leadership reflect tea-party values."

The group isn't making an official endorsement.

Virginia Rep. Eric Cantor, the second-ranking GOP leader, backed Mr. Hensarling almost immediately. "Over the last few years, there are few who have done as much for the Republican team as Jeb," Mr. Cantor wrote in his endorsement message.

The race is just one of the issues House Republicans will face as they try to balance the realities of governing with the priorities of their most-energized voters. They will soon confront a vote on raising the federal debt limit and will need to decide whether to ban earmarks, the special projects lawmakers insert into spending bills.

GOP leaders plan to hold a series of early votes on spending cuts, in part to show voters they are serious about shrinking the size of the government. They are working to beat back any notion that they are squashing an insurgent leadership bid in favor of an establishment figure.

Mr. Hensarling, they note, is one of the staunchest conservatives in Congress. Both he and Ms. Bachmann received perfect ratings from the American Conservative Union last year.

The Club for Growth, an influential small-government group, gave Mr. Hensarling a 100 rating to Ms. Bachmann's 88.

"Hensarling is a great guy," said Adam Brandon, spokesman for FreedomWorks, a group that has backed the tea parties. "He's been with us in the fight on all the important issues."

But some tea-party activists said they know little about Mr. Hensarling. Ms. Bachmann, in contrast, has been an outspoken supporter and formed a "tea party caucus" in the House.

Now, Ms. Bachmann wants to bring the movement into the GOP hierarchy. "She's worked very hard to represent the tea party in Congress," Bachmann spokesman Sergio Gor said. "It's important for a constitutional conservative to be in the Republican leadership."

Some Republicans see Ms. Bachmann as more skilled at attracting attention than performing the organizational tasks the conference chairmanship requires, such as helping Republicans make their case in the media. In 2008, for example, Ms. Bachmann created a furor by telling MSNBC's "Hardball" about then-candidate Barack Obama, "I'm very concerned that he may have anti-American views."

Mr. Hensarling said the rivalry is friendly, calling Ms. Bachmann "a great, dear friend."

"Just about by any estimation, typically I'm one of the top three or four fiscal conservatives in the House," he said in an interview. "I haven't set out to create a national profile for myself. I am who I am. Among the tea-party folks in my neck of the woods, they by and large look at me quite favorably."

The vote for conference chairman is expected this month. The House will probably vote in February on raising the debt limit so the government can continue to borrow money, something supporters say is necessary to meet the country's obligations.

Many incoming Republicans campaigned against raising the ceiling. Allen West of Florida, for example, wrote on his campaign website that the Democratic incumbent "voted to raise the debt limit, which gave Congress an artificial ceiling so they could continue to recklessly spend money."

Some conservatives want to link a debt-limit vote with a broad spending cut to make it more palatable. House Minority Leader John Boehner (R., Ohio), asked about the debt-limit vote this week, said only, "We'll be working that out over the next couple of months."

Mr. West, who enjoyed tea-party backing, said Republicans will have a few months to show voters they are more fiscally responsible than the previous GOP majority. "They can't go back to being what they were," Mr. West said in an interview. "If they don't take bold and decisive actions, they will be cast upon the ash heap as well."

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Anderson knew all about perseverance

George "Sparky" Anderson got his nickname in the minor leagues because of his spirited play. He made it to the majors for only one season, batting .218 for the Phillies in 1959.

Anderson learned to control a temper that nearly scuttled his fledgling career as a manager in the minors, and went on to become one of baseball's best at running a team. And he won with a humility that couldn't obscure his unique ability to manage people.

"I got good players, stayed out of their way, let them win a lot and then just hung around for 26 years," he said during his Hall of Fame acceptance speech in 2000.

Of course, there was a lot more to him. He liked to twist the language, using double-negatives to make a roundabout point. He also reassessed things constantly.

"To be around me, you have to be a little bit cuckoo," Anderson said on the day he resigned from the Tigers after the 1995 season. "One day it's written in concrete, the next day it's written in sand. I always felt if I didn't change my mind every 24 hours, people would find me boring."

Anderson's win total trails only those of Mack, McGraw, Tony La Russa, Bobby Cox and Joe Torre. His overall record was 2,194-1834 and he was a two-time AL Manager of the Year.

"Sparky was one of the greatest people I've met in baseball," Detroit Hall of Famer Al Kaline said. "He was a leader to his players both on and off the field. He was an incredible person and I cherish the time I was able to spend with him."

He had the right touch with superstars, and it came in handy when he led the star-studded Reds to World Series wins in 1975-76.

"He was a people person," Morgan, a Hall of Fame second baseman, told The Associated Press. "I don't think anybody else could have managed that team nearly as well as he did. We had a lot of different personalities. Sparky was able to deal with all of us on an individual basis but also collectively as a team.

"Because he was close to you and cared about you as a person, you were always willing to do more for him than you were for somebody else. I never thought of him as my manager. I thought of him as part of my family."

Anderson won four National League pennants in Cincinnati from 1970-78, then was stung when the Reds fired him after consecutive second-place finishes. Anderson took his disappointment to the other league and won there, too, directing the Tigers to the 1984 championship and a division title in 1987. He was voted into Cooperstown by the Veterans Committee.

Even then, he showed his usual self-deprecation. Anderson had refused to step foot inside the Hall until 2000 because he felt unworthy.

"I didn't ever want to go into the most precious place in the world unless I belonged," Anderson said.

For a long time, he was a long shot to make the Hall.

The only notable thing about Anderson as a player was his prematurely graying hair and his nickname. He was playing for Fort Worth in the Texas League in 1955 when a radio announcer, taken by his feisty play, started calling him Sparky.

The name stuck. He didn't. Anderson made it to the majors in 1959 and singled home the go-ahead run on opening day in Cincinnati, which turned out to be the highlight of his playing career. A light-hitting second baseman, he had 12 extra-base hits — zero home runs — and 34 RBIs in 477 at-bats.

He was back in the minors the next year, and soon realized it was time to think about another career.

He decided to try managing.

That almost flamed out, too. His first job was managing a minor league team in Toronto in 1964. He was overly aggressive in his strategy and argued every close call with umpires, showing a short fuse that soon got him fired. Cardinals general manager Bob Howsam gave him a second chance to manage in the minors, then moved to Cincinnati to build the Reds.

When he needed a big league manager there, he decided to call Anderson, who was shocked to get the chance. The youngest manager in the majors at age 35, he signed the $28,500 contract — by far the most money he'd ever made — and set out to make himself known in a city asking: Sparky who?

"Bob Howsam either had to be nuts or have a lot of savvy," Anderson said. "As it turns out, he had a lot of savvy."

Howsam assembled one of the most talented teams of all time — Bench, Morgan, Rose, Tony Perez, Ken Griffey Sr., George Foster, Davey Concepcion. Anderson was charged with making it work.

Anderson's plaque in Cooperstown calls him "the crank that turned the Big Red Machine," and his players agree that it fit. Bench noted that Anderson treated his players respectfully and was always on top of game strategy.

"It's a lot like a chess game, and Sparky was a chess master," Bench said.

In Cincinnati, Anderson also got himself another nickname: Captain Hook, a reference to his habit of pulling a starting pitcher when he got into a jam late in a game. He also showed creativity in making lineup changes.

One of the most important moves: switching Rose from left field to third base on May 3, 1975, allowing Foster to play full-time in left. It was the final piece of the Machine, which beat Boston in a dramatic seven-game Series that year, then swept to another title while winning 108 games the following season.

Two second-place seasons led to a surprising firing. Anderson moved on to Detroit, where he had more longevity and added one more title.

He refused to manage replacement players during baseball's labor dispute in spring training of 1995, angering owner Mike Ilitch. He resigned after a 60-win season, saying the franchise needed a new direction. He hoped to manage somewhere else, but when an offer never came along, he retired.

Survivors include his wife, Carol; sons Lee and Albert; daughter Shirley Englebrecht; and nine grandchildren.

___

AP Sports Writer Larry Lage in Detroit contributed to this report.

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Hall of Fame manager Sparky Anderson dead at 76

— Reds fans were taken aback when Sparky Anderson showed up in Cincinnati for his first day as a big league manager, an unknown taking over baseball's first professional team.

Sparky who?

Really?

By the time he was done, this man with the shock of white hair and schoolboy nickname would produce a considerable list of achievements that featured three World Series titles — including crowns in each league — and a Hall of Fame entry on his resume.

Anderson, who directed the Big Red Machine to back-to-back championships and won another in Detroit, died Thursday from complications of dementia in Thousand Oaks, Calif. He was 76. A day earlier, his family said he'd been placed in hospice care.

Anderson was the first manager to win World Series titles in both leagues and the only manager to lead two franchises in career wins.

"Sparky was, by far, the best manager I ever played for," said former Reds star Pete Rose, the game's career hits leader. "He understood people better than anyone I ever met. His players loved him, he loved his players, and he loved the game of baseball. There isn't another person in baseball like Sparky Anderson. He gave his whole life to the game."

Anderson's teams in Cincinnati — featuring Johnny Bench, Joe Morgan and Rose — won crowns in 1975 and 1976 and rank among the most powerful of all time. Led by Kirk Gibson and Alan Trammell, Anderson won with the Tigers in 1984.

"He was a good guy," former Tigers pitcher Jack Morris said, choking up over the news. "Baseball will have very few people like Sparky. He was a unique individual. He was a character with a great passion and love for the game."

Anderson never tried to overshadow his teams, giving his stars great leeway while trying to stay in the background. At Anderson's request, there will be no funeral or memorial service.

Always affable, ever talkative and known for a self-deprecating demeanor, Anderson was equally popular among players, fans and media.

"Revered and treasured by his players for his humility, humanity, eternal optimism and knowledge of the game," his Hall of Fame plaque reads.

Baseball Commissioner Bud Selig called Anderson a gentleman and dear friend.

"I recall with great fondness the many hours we would spend together when his Tigers came to Milwaukee," Selig said. "Sparky was a loyal friend, and whenever I would be dealing with difficult situations as commissioner, he would lift my spirits, telling me to keep my head up and that I was doing the right thing."

The Reds put a photo of Anderson on their outfield videoboard at Great American Ball Park on Thursday afternoon, honoring the man who led them to their greatest moments.

"In one way or another, Sparky touched the life of every Reds fan," owner Bob Castellini said.

Anderson's win total of 2,194 was the third highest when he retired after the 1995 season, trailing only Connie Mack and John McGraw. He's still sixth on the career list — he won 863 games in nine years with the Reds and 1,331 in 17 seasons with the Tigers.

He'll be remembered as much for the little things that made him beloved as for the big numbers that made him a Hall of Famer.

"Being a good baseball player and person went hand-in-hand with him," said Alan Trammell, the 1984 World Series MVP who is Arizona's bench coach. "He wanted us to put our dirty clothes in the bin so that the clubhouse guys didn't have to pick up after us."

In many ways away from the field, he was a teacher.

"He had a lot to do with molding me professionally and taught me a lot about perseverance," Morris said.

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Randy Moss sure to 'draw interest' from around NFL

Randy Moss figures to get plenty of interest once he clears waivers, but fitting him into a new system will present a major challenge for a team that acquires him midseason. "When the Patriots traded for Deion Branch, that was a different situation because he was already familiar with their terminology and their quarterback," said Gil Brandt, former Cowboys director of player personnel. "If a guy like Moss goes to the Dallas Cowboys, or wherever else he may go, he's got a whole new terminology to learn and a new quarterback. That makes it more difficult. It's like going to algebra class in the middle of the year. "Still, he'll draw interest. Let's say you're Tampa Bay and you're 5-2 right now. You've got a chance to be a playoff team. You might claim the guy."

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Substance Abuse Ranked According to Harm to User and Society

Nov. 1, 2010 -- Alcohol abuse is more harmful than crack or heroin abuse, according to a new study by a former British government drug advisor and other experts. Neuropharmacologist David Nutt, MD, of Imperial College London, and colleagues rated 20 different drugs on a scale that takes into account the various harms caused by a drug. Drugs are rated on nine harms a drug causes an individual and seven harms a drug causes society. The scale, developed by a panel of experts called the Independent Scientific Committee on Drugs (ICSD), ranges from 0 (no harm) to 100 (greatest possible harm). It is weighted so that a drug that scores 50 is half as harmful as a drug that scores 100. "The highest and lowest overall harm scores … are 72 for alcohol and 5 for mushrooms," Nutt and colleagues calculate. "The ICSD scores lend support to the widely accepted view that alcohol is an extremely harmful drug both to users and to society." Alcohol was found to be the most harmful drug to society and the fourth most harmful drug to users. The findings should come as no surprise: Alcohol has been linked to more than 60 diseases. "Alcohol does all kinds of things in the body, and we're not fully aware of all its effects," alcohol researcher James C. Garbutt, MD, of the University of North Carolina at Chapel Hill, recently told WebMD. "It's a pretty complicated little molecule." Heroin, crack, and crystal meth were the most harmful drugs to the individual, while alcohol, heroin and crack were the most harmful to others. According to this "multicriteria decision analysis approach," alcohol is almost three times as harmful as cocaine or tobacco. Nutt and colleagues conclude that aggressively targeting alcohol harm is “a valid and necessary public health strategy." In an editorial accompanying the Nutt team's report, Jan van Amsterdam of the Netherlands National Institute for Public Health and the Environment and Wim van den Brink of the Amsterdam Institute for Addiction research note that the legal penalties prescribed by various nations’ drug policies are out of synch with the actual harms caused by different drugs. "It is intriguing to note that the two legal drugs assessed -- alcohol and tobacco -- score in the upper segment of the ranking scale, indicating that legal drugs cause at least as much harm as do illegal substances," van Amsterdam and van den Brink write. The editorial and the Nutt study appear in the Nov. 1 Online First edition of The Lancet.

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